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Projects_main


Projects
From our inception, we have taken on the problems sought in the biomedical field. With careful design, dedicated research habits, and PERSISTENCE, we believe we can find the solutions necessary to make the world work better. 

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Projects_main


Projects
From our inception, we have taken on the problems sought in the biomedical field. With careful design, dedicated research habits, and PERSISTENCE, we believe we can find the solutions necessary to make the world work better. 

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ALL


MANUFACTURING OF ARTIFICIAL TISSUES USING HYBRID BIOMATERIALS AND A LOW-COST THREE DIMENSIONAL PRINTER

Project by Joshuah Gagan, Matthew Barnhart, Jake Fallon, Justin Pena, and Todd Schurr
One out of three people will have renal failure in the present day or the near future. It is inevitable and the current problem is finding more kidneys available for transplantation. However, there are solutions to creating artificial kidneys through tissue engineering techniques. By taking advantage of additive manufacturing, also known as three-dimensional printing, it is possible to develop and engineer a fully functional kidney using biomaterials. In addition, biomaterials are able to contain multipotent stem cells, which are designed to differentiate into the appropriate cell during organ development. Our lab is designed to getting one step closer to find what makes stem cells compatible with biomaterials and in hopes that one day we can implant an artificial kidney in vivo.


INVESTIGATION OF NEUTROPHIL 3D CHEMOTAXIS THROUGH FORCE GENERATION

Project by Rodolfo Amezcua and Tahani Bulushi
Neutrophils are a vital part of the innate immune response due to their capability of migrating towards and eradicating pathogenic bacteria. However, under septic conditions neutrophil usual migratory behavior is impaired, particularly chemotaxis. In order explain the impaired neutrophil behavior, our lab studies the force generation mechanisms of the cell during chemotaxis within a 3D collagen gel. After doing so we can better predict cellular behavior and aid in developing an effective treatment for sepsis.


Starch-based Biomaterials for stem cell therapies

To be discussed later...


CARDIOVASCULAR NANO-BIOMATERIALS: THE NANO-HEART PATCH

Project by Gina Vimbela and Alejandra Juarez
The combination of multiple biological fields—cell biology, physiology and histology—joined with new advancements in material sciences and engineering at the nanoscale level (one physical dimension between 1-100 nm) has generated “nano-biomaterials.” The introduction of these “nanomaterials,” from the advent of nanomedicine, has revolutionized the field of biomedical research. One recent advancement that our group has developed is the use of nanomaterials is the combination of poly lactic-co-glycolic acid (PLGA) with embedded CNFs to construct a conductive composite “patch” for the dead tissue zone (infarct area) of the heart. Our research has demonstrate that the use of nanotechnology can improve myocardial tissue engineering applications through the addition of CNFs to PLGA showing promising results for future CVD applications and research. 


DEVELOPING CONTRACEPTIVES THAT INCREASE STIMULATION

Project by Matthew Barnhart
There are approximately 34 million people living with HIV/AIDS, with another 30 million that have died since 1981. Today, there is still not cure for this deadly disease, but research has shown that the use of contraceptives can drastically reduce the risk of HIV/AIDS when used properly. So with this knowledge, why do men still not apply this knowledge? According to estimates, global awareness campaigns of sexually transmitted diseases has increased public knowledge by an astounding 57%. However, the male condom is only a small subset of that percentage and represents only one of two methods of safe sex available to men, with the other being the vasectomy. Despite these numbers, only 1 in 4 men reported having used a condom in their most recent session of vaginal intercourse. When investigated upon, men state that the use of a condom reduces the sensation of pleasure. To answer this age old question, we have designed an innovative condom construct created to not only increase the sexual experience of partners during intercourse, but as a new design to help bring about protection against sexually transmitted diseases, including the HIV/AIDS virus, among those whom are sexually active.


Encapsulating pacreatic islets in alginate

To be discussed later...


DEVELOPING BONE FROM OSTEOBLASTS USING ADDITIVE MANUFACTURING

Project by Jennifer Ngo
The test of biocompatibility of 3D printing bones with cells shows whether 3D printed bones would work in a body. As detailed a 3D printed bone can be replicated to the real thing, if it does not respond well in a body then it is useless. To test for the biocompatibility of 3D printed bones, the bones are put in an environment that are similar to the body that it is put in. Since one of the goals for 3D printed bones are for humans to function normally with the product, the replicated environment will be similar to the human body. Using cells that are seen in the human body, such as osteoblast, there is an observation whether the cells with live and adapt to the 3D printed bone materials, or respond negatively and die.


Development of a device for the control of ferrofluids

To be discussed...